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The chamber was preset to 10% CO 2 at 33 during the culture phase

10.1038/s41419-018-0381-8 128 WangW

Specifically, through the formation of disulfide bonds between catalytic cysteines, H 2 O 2 inactivates phosphatase and tensin homolog phosphatase (PTEN) and unlocks the phosphoinositide 3-kinase (PI3-K)-dependent recruitment of its downstream kinases, such as protein kinase B (Akt) 16 , or oxidizes the redox protein thioredoxin and thus suppresses its inhibitory effect on the p38MAPK signaling cascade 17

12,44,45 Consistent with the biochemistry of carbohydrate metabolism, people with lower fasting glucose levels show diminished incidence and delayed progression of all cataract subtypes