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Conversely, reducing the glycolytic activity in T cells, such as through inactivation of the glycolytic master regulator HIF-1, promotes a shift in CD8 T cells towards greater reliance on mitochondrial respiration, thereby enhancing their stemness during chronic viral infection [18]
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There, albumin-bound bilirubin is able to pass through the fenestrations and, via an active transport process in the hepatocyte membrane (binding to glutathione S-transferase , aka ligandin), moves to the endoplasmic reticulum, where it undergoes conjugation
TDP-43 Proteinopathy and ALS: insights into disease mechanisms and therapeutic targets
