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Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

With regard to tGSH levels (a) no significant change was observed in old versus young adults (Pardo-Andreu et al., 2006), but (b) a decrease with age was reported in old adult sub-groups (ages 6066, 7278, 8187 and 90 yrs) (Prez et al., 2020)

This dysfunction is especially noticeable in neurological disorders, emphasizing how problems at the mitochondrial interface spread cellular damage