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In addition, TD is difficult to diagnose because there are no cheap and reliable laboratory tests to detect the deficiency-serum thiamine levels are not adequate to determine the body's supply of thiamine

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Whenever the concentrations of H2O2 are in a high level, CAT becomes more effective than GPX and vice versa [59]

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Employing a lipophilic prodrug charge masking approach to change the polarity of hydrophilic peptides, such as with lipid derivatives of cyclic N-methylated hexapeptide containing Arg-Gly-Asp (RGD) showed that the derivatized peptides traversed mucosal membrane via the transcellular pathway in the Caco cell model to enhance polar peptide permeability [77]

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