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These findings confirmed the concept that D3 is essential for the early stages of tumorigenesis [38, 63] and demonstrated that an enhanced TH signal is associated with high metastatic risk

This process, while seemingly paradoxical, can lead to significant tissue damage and cell death, often exceeding the initial injury caused by ischemia alone[323, 324]
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This challenge has prompted the exploration of natural sulfur compounds, which can increase the sulfur pool in the cell in a more controlled and sustained way, providing a more effective solution for therapeutic applications
