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[DOI] [PMC free article] [PubMed] [Google Scholar] 64.Swaminathan S., Birudukota S., Thakur M

Studies have consistently reported that inhibiting NNMT activity or downregulating NNMT expression leads to significant increases in NAD + levels in mouse adipocytes (Neelakantan et al., 2018) and hepatocytes (Song et al., 2020)

[1] Niacinamide in high doses can sometimes cause nausea, heartburn, or a sensation of warmth

This article covers their mechanisms, clinical data, side effect profiles, and which research contexts favour one compound over the other
