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Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma

This dark reddish-brown, wedge-shaped organ serves the body with everything from digestion to detoxification

Inactivation of the detoxifying enzyme glutathione -S- transferase has been observed in cells exposed in vitro to busulfan and, because of the inactivation of the enzyme, the level of free electrophilic species in the tissues of the exposed organisms can increase to levels that irreversibly damage the cell, which is deranged to apoptotic or necrotic death