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Cash A, Kaufman DL

The essential role of the E1, E2 transmembrane domains in the viral entry[150] and the involvement of different regions of the ectodomain of E2 in the viral assembly were demonstrated[151]

In this process, pyruvate, a metabolite of glucose, enters the mitochondria, where it undergoes oxidative decarboxylation through the pyruvate dehydrogenase complex to form acetyl-CoA

Other tests would be needed to diagnose exocrine pancreatic insufficiency (i.e., inadequate enzyme production)