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Drug dosage was calculated by dividing the average prescribed daily dose by the WHO-assigned DDD for each drug

burgdorferi sensu lato ( Ixodes ticks which transmit the disease are commonly found throughout temperate regions of North America, Europe, and Asia ( Clinically, Lyme disease presents with dermatologic and/or viral-like signs and symptoms such as intermittent fever, sweats, chills, malaise, fatigue, and achiness during the acute phase, which can transition to neurologic, cardiac, and/or joint involvement in later stages of the infection as the bacteria disseminate hematogenously ( B

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Chen WP, Xiong Y, Shi YX, Hu PF, Bao JP, Wu LD (2014) Astaxanthin reduces matrix metalloproteinase expression in human chondrocytes