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Our synthesis aims to pave the way for future investigations into lipid-centric strategies to combat depression, advocating for a metabolic reorientation in mental health therapeutics

With a cutoff of 0.69-1% for a positive test, most studies with commercially available dd-cfDNA assays demonstrate an AUC at 0.71-0.85, with a sensitivity and specificity of 45-89% and 69-85%, respectively, and a positive and negative predictive value of 52-77% and 66-95%, respectively, when compared with renal pathology, depending on the pretest probability of rejection (39)

1,2,12 Regular follow-up and monitoring Given that MAFLD is a slowly progressive disease, clinicians should pay more attention to patients lifestyles and regularly monitor their blood biochemical indicators, steatosis degree, and fibrosis stage

These studies position lactylation as a crucial player in the pathophysiological processes of various diseases, significantly expanding our understanding of the role of lactate in disease contexts