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Trx1(SH) 2 catalyzes denitrosylation of caspase3 nitrosylated at Cys163, whereas Trx1SNO prevents apoptosis by transnitrosylating caspase3 at the same cysteine residue and induces oncogenic cell transformation [134, 136-138]

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Abbreviations NAFLD: Non-alcoholic fatty liver disease NASH: Non-alcoholic steatohepatitis DNL: De-novo lipogenesis TNF: alphaTumour necrosis factor APN: Adiponectin HCC: Hepatocellular carcinoma MS: Metabolic syndrome FFA: Free fatty acids ACC: Acetyl COA carboxylase SREBP: 1Sterol regulatory element binding protein ChREBP: Carbohydrate response element binding protein ER: Endoplasmic reticulum MHC: Major histocompatibility test ETC: Electron transport chain SODS: Superoxide dismutase GSH: Growth stimulating factor LCFAS: Long chain fatty acids PUFA: Polyunsaturated fatty acids LDs: Lipid droplets TGs: Triglycerides References Yi J, Pan J, Zhang S, Mao W, Wang J, Wang W, Yan Z (2022) Improvement of chronic non-bacterial prostatitis by Jiedu Huoxue decoction through inhibiting TGF-/SMAD signaling pathway