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fumigatus (Fig

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FIGURE 3 Clinical studies have reported controversial results despite the support from preclinical studies (Table 2)

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Targeted pharmacological interventions along these pathways have shown therapeutic promise in models of ischemic brain injury, neurodegeneration, and cancer

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Since vascular growth is not only up-regulated but also accompanied by significant changes in their architecture (i.e., abnormal vasculature, disorganization, etc.) and function [129,130], a tumor burdened with those vessels may eventually be resistant to various therapeutic methods, including systemic treatment in the form of chemotherapy or radiotherapy [131]

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