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FIGURE 3 Clinical studies have reported controversial results despite the support from preclinical studies (Table 2)
Targeted pharmacological interventions along these pathways have shown therapeutic promise in models of ischemic brain injury, neurodegeneration, and cancer
Since vascular growth is not only up-regulated but also accompanied by significant changes in their architecture (i.e., abnormal vasculature, disorganization, etc.) and function [129,130], a tumor burdened with those vessels may eventually be resistant to various therapeutic methods, including systemic treatment in the form of chemotherapy or radiotherapy [131]
