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Balashova OA, Visina O, Borodinsky LN

By comparing the resilience of these two cell lines, this work provides novel insights into the biochemical alterations and adaptive responses to oxidative stress at the cellular level

After mutation of the PAZ RNA-binding pocket (F294A, Y311A), trigger variants with longer internal loops induced binding and polyubiquitylation no better than did the seed-only variant, supporting the idea that together, trigger-specific RNA trajectory and binding of the vacated PAZ pocket substantially contribute to ZSWIM8 selectivity for TDMD substrates