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Updated 7/28/2021
The tracker below denotes how much Tier 2 funding has been spent and how much remains available

Circulating monocytes from RA patients produce elevated levels of IL-1 and IL-6 upon in vitro stimulation (69), IL-6 contributes to joint destruction (70), while IL-1 promotes osteoclastogenesis, induces matrix metalloproteinase (MMP) expression in chondrocytes, and initiates synoviocyte proliferation (71)

Clinical practitioners who administer this combination report side effect profiles consistent with each compound used individually
