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Description
Azinomycin B (AZB), a secondary metabolite produced by soil-dwell bacteria Streptomyces sahachiroi and Streptomyces griseofuscus , induces ICLs in the DNA duplex by nucleophilic addition at the N7 positions of purines (Wang et al., 2016)

Active compound: Nicotinamide n-methyltransferase

International retrospective analysis of 73 cases of invasive fusariosis treated with voriconazole

Conversely, the deacetylation of histones by histone deacetylases (HDAC) restricts access of transcription factors to the DNA and suppresses transcription
