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The E3 Ligase MIB1 promotes proteasomal degradation of nrf2 and sensitizes lung cancer cells to ferroptosis

Claudia Bregonzio, CCT CONICET Crdoba, Argentina

Extensive evidence shows that the intestinal microbiota in UC differs markedly from that of healthy individuals, with depletion of beneficial commensals and expansion of potentially harmful taxa (Hansen et al., 2010

This dynamic interaction between inflammation, oxidative stress, and BBB breakdown contributes significantly to the progression of neurodegenerative diseases such as AD and PD and underscores the importance of targeting both oxidative stress and inflammation in therapeutic strategies [56,144,196]