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Isenberg DA, Furie RA, Jones N et al (2021) Efficacy, safety, and pharmacodynamic effects of the Brutons tyrosine kinase inhibitor fenebrutinib (GDC-0853) in systemic lupus erythematosus: results of a phase II, randomized, double-blind, placebo-controlled trial

To visualize all extreme agers, age gaps were denoised by setting values below absolute z-score of 2 to zero
SARS-CoV-2 infection alters phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), Type I and III interferon, transforming growth factor- (TGF-), Toll-like receptors (TLR), and nuclear factor kappa-light chain enhancer (NF-B) pathways