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Additionally, anthocyanin supplementation exhibits neuroprotective effects in PD mice (10, 20, 40 mg/kg/day for 4 weeks) (62) and high-fat diet-induced obese rats (25 mg/kg/day for 17 weeks) (63) by modulation the composition and metabolism of gut microbiota

This strategy aims to bypass impaired conversion and provide direct hormonal activation, though it must be personalized and initiated with caution

For instance, AtDHAR1 is up-regulated in response to norflurazon, menadione, paraquat, and antimycin A, treatments known to produce reactive oxygen species (Chew et al., AtDHAR2 expression is induced in root cell cultures in response to BSO and chloro-dinitrobenzene (CDNB) (Dixon et al., DHARs are not always regulated in the same manner in response to stress conditions

B., Thornton, F