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MIF contribution to progressive brain diseases
This model is supported by evidence from various experimental systems, including the ability of lactate to sustain synaptic function in vitro (Schurr et al., 1988), the cellular localization of relevant transporters and enzymes, and in vivo studies using microsensors that report rapid lactate consumption coupled to oxygen utilization in the tissue parenchyma during activation (Hu and Wilson, 1997)
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