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TMAO induces ERS via PERK/FoxO1 activation, decreasing insulin receptor expression and causing insulin resistance (81)

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Cell damage and integrity during permeabilization has been assessed by fluorescent probe uptake assays (such as 1-phenylnaphthylamine or NPN) [78], protein cell leakage, transmission electron microscopy (cell structural alterations) and transport assays with L [ N-methyl 14 C]carnitine (specific carrier transport studies) [76]

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*These data are based on self-report and are therefore prone to possibly inaccurate memory

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Eur J Biochem 191:483489, 1990

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