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Annu Rev Pharmacol Toxicol (2020) 60:63759

The P4 contained similar peptide patterns with the major pentapeptide (TSNTF), but lacking the 871.45 Da peptide

This remains an actively moving area, however: on February 27, 2026, the HHS Secretary publicly announced an intent to move roughly 14 of the 19 Category 2-listed peptides, reportedly including ipamorelin and CJC-1295, back toward Category 1 status, and multiple industry and legal-news outlets reported further FDA action in the following months easing Category 2-related restrictions on this group of peptides

In the practice of clinical diagnosis, the analysis of large proteins is much more complicated than that of small-molecule compounds (Chen et al