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The death of mature oligodendrocytes also promotes neuroinflammation and oxidative stress stimulation

This effect is partly mediated through upregulation of anti-apoptotic proteins such as B-cell lymphoma 2 (Bcl-2), and downregulation of pro-apoptotic proteins such as tumour protein 53 and Bcl-2-associated X protein, collectively enhancing neuronal survival [50]

This paper reviews the physiological functions of selenoproteins in resisting oxidative stress in aquatic animals, the mechanisms of different forms of Se in anti-oxidative stress in aquatic animals and the harmful effects of lower and higher levels of Se in aquaculture

Strikingly, a high number of proteins more than 80% from all models exhibited differential mean expression between control and cKOt mice (Figure 1J), demonstrating the substantial effect of Bmal1 deletion on the renal proteome
