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The pivotal human trial used oral tablets
221 This is the case of MKN28 cancer cell line, where no mRNA nor protein expression was found due to high methylation of NAPRT promoter region
Additional ferroptosis buffering pathways include ferroptosis suppressor protein 1 (FSP1), which regenerates reducing elements in the plasma membrane, such as CoQ or vitamin K, that can terminate the lipid peroxidation process
This can ultimately lead to neuronal cell death, further contributing to the neurodegenerative process [109,110]
