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Nevertheless, supplementing the diet of weaned piglets with 0.1% or 1.0% GSH did not change the level of GSH in mucosa of the small intestine, liver tissue, and blood erythrocytes

10.1182/blood-2003-01-0288 112 PortoB

If the Sigma-1 receptor is involved in the response to cortisol or the response to stress, that would explain why, if animals dont have it, they have a more chronically elevated stress response because their cells are not responding to the stress hormones, so theyre trying to compensate for that by making more stress hormones

Autophagy level detection AF cells were incubated at a density of 2 10 5 on 24-well plates under complete medium cultivation