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Goh et al., 2014

[32] [33] Research [edit source] Treatment of sarcoma, especially when the sarcoma has spread, or "metastasized", often requires chemotherapy
As an alternative methyl donor, betaine plays a central role in maintaining methylation capacity, and its depletion may contribute to elevations in S-adenosylhomocysteine and impaired methyltransferase activity
