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A review of the literature on drug intervention for disulfidptosis target genes and signaling pathways may provide new directions for research on CNS therapy

doi: 10.1089/cbr.1995.10.153

Biochem Biophys Res Commun 524(4):895902 Gureev A, Krutskikh E (2025) Regulation of the NRF2 transcription factor activity by SIRT1-induced deacetylation: a possible SIRT1NRF2 feedback loop

The well-defined genetic etiologies, confined neuroanatomical involvement, and stereotypic clinical progression of these optic neuropathies make them invaluable for dissecting how specific mitochondrial defects lead to neuronal dysfunction, yielding insights that inform our understanding of more complex neurodegenerative conditions