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Furthermore, as highlighted in the previous section regarding therapeutic strategies, the critical relationship between immunosenescence and inflammation has prompted clinical trials to investigate targeting macrophages (NCT01045512), endothelial cells (NCT04537884), and neutrophils (NCT02441205) (Table 2) in an effort to mitigate immunosenescence and combat conditions such as congestive heart failure, neovascular age-related macular degeneration, and diabetes

Antibodies against DKK1 have also been used to treat mouse models of multiple myeloma (Yaccoby et al., 2007) and osteoarthritis (Diarra et al., 2007), both of which are associated with bone tissue loss