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Primary risks include additive cardiovascular effects (increased heart rate and blood pressure), intensified gastrointestinal symptoms (nausea, vomiting, diarrhea), and potential for serious adverse events including pancreatitis and acute kidney injury requiring close monitoring

Unfortunately, these studies failed to demonstrate a link between removing amyloid plaques and any significant cognitive improvements

Rarely, allergic reactions can occur, presenting as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat

Prasad S, Huang J, Zeng Q, Brooks BR (2018) An explicit-solvent hybrid QM and MM approach for predicting pKa of small molecules in SAMPL6 challenge