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Animal studies indicate that combining NAC with low-dose estrogen offers similar protection against cardiac dysfunction and metabolic syndrome as standard-dose estrogen therapy, but with potentially fewer risks.[2,3] NAC alone also improves markers of oxidative stress, cholesterol, and inflammation in models of menopause, suggesting it may help mitigate heart disease risk.[4] 3

Finally, epigenetic regulation via histone modification, such as acetylation of methylation at the NLRP3 promoter and DNA methylation, silences NLRP3 expression and further refines its transcriptional control, highlighting the intricate regulation of this critical inflammasome component [52]

[] A summary of all clinically proven natural products described in this study is provided in Table 1