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10.1126/sciadv.adj1092 167 MitreaL.NemeS.-A.SzaboK.TelekyB.-E.VodnarD.-C

In the model proposed by Lee, homocysteine is shunted away from the methionine synthesis pathway and toward the GSH synthesis pathway, creating a relative deficiency of methyl donors in order to keep up with increased demand for the glutathione needed for POP conjugation ( Fig 3 )

surface of the CTR that controls binding and signaling of distinct CT and related peptides

Our results strikingly parallel this model and suggest that neuropeptide signalling in-phase with core clock gene transcription is a conserved principle for achieving pacemaker neuron synchrony