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Since B12 is water-soluble, your body excretes what it doesnt use, making it generally safe, even in higher doses [*]

The over-expression of APX has been shown to confer tolerance to various abiotic stresses (Xu et al., 2008

Veljaca, Marija et al, The development of PL 14736 for treatment of inflammatory bowel disease, Advanced in GI pharmacology, 2002 O-32

Biosynthesis of ascorbate in yeast
