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These fatty acids induce ferroptosis through esterification and incorporation into cellular membrane phospholipids (67)

All participants were M0 at diagnosis with no metastatic disease

A refined definition of astrocyte reactivity includes four key features: (1) cellular, molecular and functional changes in response to CNS insults, (2) graded responses depending on insult severity, (3) context-dependent reactions influenced by intra- and intercellular signaling and (4) beneficial or detrimental effects on surrounding cells 35