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Neurological issues brought on by pernicious anemia include memory and concentration issues, tingling and numbness in the hands and feet, and balance issues Pernicious anemia can lead to nerve damage Pernicious anemia can lead to heart failure Pernicious anemia can lead to an increased risk of infection and cancer Birth abnormalities and pregnancy difficulties including miscarriage can result from pernicious anemia

(2008) Biomaterials Study examining AOD 9604 effects on vascular endothelial growth factor production and neovascularization in engineered cartilage

hence, a deficiency can occur