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Purity was then normalized between time points by setting the purity at time 0 ( T = 0) to 100 for each formulation, as follows: From the normalized area-% results, a degradation slope was calculated using linear regression

Therefore, tyrosinase is active with monophenols such as: umbelliferone 196 , hydroquinone 197 , 198 p- hydroxybenzyl alcohol 199 , 4-hexylresorcinol 200 , oxyresveratrol 201 , 4- n -butylresorcinol 202 , resorcinols 203 , and -arbutin 195 and p- coumaric acid 204 , 205 when we add the following reagents to medium of reaction: hydrogen peroxide (transforms E m to E ox ), an o- diphenol or a reducing agent such as ascorbic acid transforming E m to E d which, with molecular oxygen, is transformed into E ox

21 In addition, amantadine was found to have marked benefits in global outcome

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