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Increased resistance to quinolones has now become a major concern in reducing the clinical efficacy of levofloxacin-containing therapy

As of mid-2024, there are five DOACs approved for use in the United States: Betrixaban (Bevyxxa) Rivaroxaban (Xarelto) Apixaban (Eliquis) Edoxaban (Savaysa) Dabigatran (Pradaxa) The mechanism(s) by which DOACs work differ from those of two other common anticoagulants: Warfarin inhibits clotting by acting as a vitamin K antagonist, and Heparin/low-molecular weight heparin works by activating antithrombin, which inactivates the coagulation enzymes thrombin, factor Xa, and factor IXa

The role of cMOAT in MDR needs to be determined

44.0 44.1 Fechtner RD, Realini T