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Description
Alleviation of the macrophage cholesterol burden is critical to the inhibition of plaque progression as excess membrane FC promotes inflammatory signaling and cell death (Discussed later)
It appears to have bidirectional immunomodulatory effects enhancing immune response under suppression and reducing it under excessive activation, making it valuable for immune regulation research
The human evidence is limited, but the mechanistic rationale is enough that this remains an active research area
doi: 10.1016/j.mam.2008.08.006 83 FossumC
