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"Proton Pump Inhibitors, H2-Receptor Antagonists, Metformin, and Vitamin B-12 Deficiency: Clinical Implications"
(91) reported their findings from a longitudinal study where they analyzed DNA methylation in leukocytes from 10 participants occupationally exposed to nanoparticles and 4 non-exposed controls over the course of 4 years

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The experimental animals condition should be meticulously observed following the procedure