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The compound's development represents years of medicinal chemistry optimization, resulting in a 10-fold improvement in potency over parent compounds while maintaining excellent safety margins in preclinical studies

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These data, along with the positive associations observed between SBP and both urinary hyaluronidase activity and AQP2/creatinine ratio, support the existence of a close relationship between renal hyaluronidases and vasopressinergic system activation, which could affect water metabolism under both normotensive and sustained hypertensive conditions

As fir the cost, it was 100$ less than last clinic I went to with same results
