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In refrigerated storage, erythrocytes develop storage lesions, characterized by oxidative alterations of membrane lipids, fragmentation of essential cytoskeletal proteins, and a gradual decline in deformability

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While individual responses vary and no universally standardized protocol exists, research and practical experience have established reasonable guidelines

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N Engl J Med (2021) 385(18):166979

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2020, doi:10.1002/hep4.1658 The biomarkers of bone metabolism reflect the dynamic nature of bone as well as its strengths and vulnerabilities

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