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However, when the extent of hepatocyte damage exceeds their capacity for self-replication, other liver cells are activated to undergo dedifferentiation or transdifferentiation, thereby compensating for the lost tissue

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Mice lacking PKM2 exhibit increased oxidative damage and dopaminergic neuron loss [31]

10.1093/jn/116.4.641 126 WiedemannC.KumarA.LangA.OhlenschlagerO