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10.1093/toxres/tfac087 18 BrowneP.Paul FriedmanK.BoekelheideK.ThomasR

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Melatonin interferes in the desmoplastic reaction in breast cancer by regulating cytokine production

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Further investigations identified the hepatic rat enzyme with GST B (nowadays called RnoGST A1-1) and it was furthermore found that purified human hepatic GSTs from the Jakoby laboratory displayed even higher specific activity than the rat enzyme ( In retrospect, it is clear that the ketosteroid isomerase activity of the GST in human liver ( 1 B 1 and B 1 B 2 in Stockman et al., 1985)

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Based on these previous findings, GSH and its constituents are expected to play vital roles in protecting cells from UV through the antioxidant defense by eliminating ROS and direct protection and repair of cells and DNA

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