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In the central nervous system, niacin is known as a key mediator of neuronal development and survival ( Current evidence has shown that a deficit of mitochondrial energy metabolism is involved in the pathogenesis of migraine headaches ( Pantothenic acid Pantothenic acid is involved in the biosynthesis of coenzyme A, cholesterol, fatty acids, and acetylcholine ( Current evidence suggests that pantothenic acid deficiency causes neurological disturbances ( Pyridoxin Vitamin B6 consists of three main forms including pyridoxine, pyridoxamine, and pyridoxal

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Those patients with immune-related disorders such as HIV or are allergic to lidocaine are also not candidates