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The involvement of common pathways in some forms of cochlear pathogenesis suggests that the combination of two or more forms may lead to even greater damage

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

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They include (1) activation of GSH biosynthesis via supplementation of substrates and energy, (2) increased enzymatic potential to produce GSH and reduce GSSG, (3) increased activities of detoxification enzymes that use GSH, and (4) activation of routes for extrusion of GSSG and glutathione S -conjugates from cells

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An increase in probiotic Bifidobacterium was detected in all donors (Jimnez-Arroyo et al., 2023)

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