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The most telling safety metric is how many people stop taking the medication because of side effects
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However, heterogeneity decreased importantly when excluding outliers (between-study variance=0.59, I 2 =73%), including only patients with moderate-to-severe AD (between-study variance=0.18, I2=44%), restricting to industry-sponsored trials (between-study variance=0.16, I 2 =43%) and using IPD only (between-study variance=0.12, I 2 =29%)
Cancer therapeutics: understanding the mechanism of action
