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Description
FDA approval of metformin for diabetes does not mean FDA approval for longevity use - those are distinct regulatory determinations, and the longevity indication is off-label
Dose-dependent effects of recombinant human insulin-like growth factor (IGF)-I/IGF binding protein-3 complex on overnight growth hormone secretion and insulin sensitivity in type 1 diabetes

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Their robust metabolic effects, alongside preliminary histological benefits, position this class as a promising option for future MASLD therapy