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Hum Reprod Update (2000) 6(1):6774
doi: 10.1038/s41574-024-00989-7 11 BiondiB.CooperD
The Cytoskeleton-Autophagy Connection
While the familial forms of PD, that have been described, involve mutations in a number of genes (Trinh and Farrer, 2013), mitochondrial dysfunction, neuroinflammation and environmental factors are increasingly appreciated as key determinants of dopaminergic neuronal susceptibility in PD, and are a feature of both familial and sporadic forms of the disease (Ryan et al., 2015)
