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Description
Here, we reveal that the aldehyde derivative of UNC10088 promotes cooperative binding of FBXO22 to NSD2, a histone methyltransferase and oncogenic protein, leading to a cryo-EM structure of the SKP1-CUL1-F-box (SCF)-FBXO22 complex with NSD2
In research, it functions as a melanocortin receptor agonist derived from the C-terminal region of -MSH
This multi-year initiative will expand Medi-Cal members' access to lifesaving gene therapies for sickle cell disease (SCD), a severe genetic blood disorder that disproportionately affects people of African descent
Juvekar, A
