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Overall, sirtuins have emerged as key actors in the efforts to understand and characterize how NAD + levels affect cellular homeostasis in a wide variety of cellular processes that impact ageing (Supplementary Box 2), and boosting their activity is a key focus of therapies aimed at counteracting ageing

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In our study, we found that the apoptosis of GABAergic neurons induced by sulindac was also accompanied by autophagy, and 3-MA, an inhibitor of autophagy, not only significantly attenuated sulindac-induced autophagy in larval zebrafish neurons but also significantly reduced neuronal apoptosis