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Published in November 1955 in the Proceedings of the National Academy of Sciences (PNAS), Jerne's paper put to rest a debate that had been raging since the late nineteenth century
doi: 10.1007/978-1-4684-3270-1_45
After being absorbed by HCC cells, the Cu 2+ and disulfide bond ( SS) in MONs@MOF-199 nanoparticles react with GSH in a redox reaction, and the nanostructure collapses, releasing DOX and SOR to exude their anti-tumor effects
