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Analysis of SDC2 gene promoter methylation in whole blood for noninvasive early detection of colorectal cancer
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ROS can stimulate Nrf2, which activates Klf9 (Kruppel like factor 9), which then activates ERK1/2, resulting in increased intracellular ROS generation in cancer cells

The brains restricted antioxidant capacity, high energy demand, high levels of transition metals, such as iron and copper, and a high concentration of polyunsaturated fatty acids which can be subjected to lipid peroxidation [103105] make the nervous system particularly vulnerable to oxidative stress [106]
